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diagnosis rheumatology treatment oncology differential leukemia workup chronic cll hemolytic lymphocytic syndrome acquired agglutinin ckd classification cold colon common crohns
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
hemolysis, deficiency anemia ... Malignancy: Metastatic cancer ... , Lymphoma, Rebound ... Rheumatologic, Vasculitides ... , IBD, Celiac disease
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immune hemolytic anemia ... number of sites of disease ... classification #hematology ... #oncology #management
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... • Sickle cells ... cardiac valve, vasculitis ... #workup #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
disorders (e.g. lymphoma ... thrombocythemia), Autoimmune disease ... adsorption onto cancer ... cells (and subsequent ... #treatment #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
hepatitis • Lymphoma ... or other cancers ... • Nodules • Lymphoid ... autoimmune hemolytic anemia ... hypogammaglobulinemia #immunology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... or basket cells ... can indicate disease ... • Neutropenia, anemia ... workup #oncology #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Malignancy (e.g. hematologic ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia ... leukemia • Lung cancer ... • Cervical cancer
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... autoimmune disorder or lymphoid ... - Monoclonal - Lymphoid ... sensitize red blood cells ... #hematology #diagnosis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
) • Cutaneous vasculitis ... Nephrogenic DI Hematologic ... : 2% Systemic Vasculitis ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hodgkin, T-cell lymphoma ... , B-cell lymphoma ... B-LNH), solid cancers ... • Autoimmune diseases ... Lymphohistiocytosis #diagnosis #management
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