11 results
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
bone marrow and peripheral ... leukopenia) Peripheral ... Smear: • Dysplastic ... blood smear • ... #hematology #oncology
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... polychromatophilic cells ... smear changes are ... D-dimer, egg) are required ... #Hematology #Pathology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... Syndrome (MD) - ... = funny-shaped cells ... cytopenias (usually anemia ... #treatment #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
Abnormalities: macrocytic anemia ... multiple myeloma, myelodysplastic ... multiple myeloma or myelodysplastic ... including peripheral ... Autoinflammatory #Somatic #rheumatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Normal Blood Smear ... Dysplastic • Myelodysplastic ... Syndromes Macrocytosis ... , Target Cells, ... Algorithm #Causes #Hematology
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Acquired von Willebrand ... Syndrome - Diagnosis ... and Management ... disorders • Shear ... #treatment #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
• Hypocellular myelodysplastic ... syndrome (MDS) ... ) Labs: • Peripheral ... #oncology #hematology ... #diagnosis #management
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or ... develop leukostasis syndrome ... - infiltrates (anemia ... smear: Blasts ... • Tumor lysis syndrome
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Diagnosis: • Peripheral ... smear → small rnature-appearing ... lymphocytes, smudge cells ... 5) Symptoms of anemia ... hemeonc #diagnosis #management
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
cytometry • Peripheral ... smear: Smudge cells ... • Neutropenia, anemia ... • Richter’s Syndrome ... leukemia • Sezary syndrome