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Multi-System Inflammatory Syndrome in Children (MIS-C) vs. Kawasaki Disease
CDC Case Definition for MIS-C;
 • < 21
Multi-System Inflammatory ... Syndrome in Children ... Kawasaki Disease ... Comparison #diagnosis #peds ... #Syndrome #Children
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
arteritis - Inflammatory ... Churg-Strauss syndrome ... - Schnitzler syndrome ... - Sjögren syndrome ... Vessels #Diagnosis #Rheumatology
Idiopathic Inflammatory Myopathies - 
Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory ... Antisynthetase Syndrome ... TerrierBen #Inflammatory ... Myopathy #Comparison #Managment ... #algorithm #Rheumatology
Causes of Pediatric Diarrhea - Differential Diagnosis Algorithm
Infectious:
 • Viral
 • Bacterial
 • Parasitic
Malabsorption:
 • Lactase
Fibrosis • Celiac Disease ... Laxative Abuse • Inflammatory ... Bowel Disease ... • Short Bowel Syndrome ... Algorithm #Causes #Peds
Behcet's Syndrome - Treatment
Ulcers:
 • Treatment: Topical steroids
 • Prevention: Colchicine
 • Azathioprine for refractory disease
Arthritis:
Behcet's Syndrome ... immunosuppressive meds ... #Syndrome #Treatment ... #management #pharmacology ... #rheumatology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... and/or 2) Inflammatory ... hematopoietic stem cells ... blood myeloid cells ... Autoinflammatory #Somatic #rheumatology
Adult Onset Still's Disease - Yamaguchi Criteria
Major criteria:
 - Fever >= 39C lasting >= 1 weeks
Onset Still's Disease ... Leukocytosis >= 10,000 cells ... lymphomas - Inflammatory ... disease, especially ... #Major #Minor #Rheumatology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Congenital Diseases ... Wiskott-Aldrich syndrome ... • Lymphoma Inflammatory ... and Autoimmune Diseases ... Differential #Diagnosis #Hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
background of a highly inflammatory ... disease How? ... release of pro-inflammatory ... #Diagnosis #Management ... #Hematology #Rheumatology
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Diagnosis and Management ... thrombocythemia), Autoimmune disease ... adsorption onto cancer cells ... #treatment #hematology