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A normal peripheral blood smear indicates the appropriate appearance of red blood cells, with a zone
smear indicates ... cells, with a zone ... the size of the RBC ... Clinical #Path #Microscopy ... PeripheralBloodSmear #BloodSmear
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
- Differential ... Diagnosis Algorithm Blood ... on Smear • Chronic ... Spherocytes on Smear ... Classification #Approach #Differential
Here is another peripheral blood smear demonstrating changes with iron deficiency anemia. Note the increased zone
another peripheral blood ... smear demonstrating ... iron deficiency anemia ... Clinical #Path #Microscopy ... PeripheralBloodSmear #BloodSmear
Dacrocytes (tear drop cells) 
Other poikilocytes resemble a pear or teardrop. The narrow, tapered end
may be
Dacrocytes (tear drop cells ... metaplasia, pernicious anemia ... some hemolytic anemias ... Clinical #Path #BloodSmear ... #Blood #Smear #
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood ... Smear Analysis ... #Peripheral #Blood ... #Smear #Analysis ... #hematology #microscopy
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
process whereby red cells ... individual’s red blood ... cells (RBCs or ... Clinical #Path #Blood ... #Smear #Microscopy
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
process whereby red cells ... individual’s red blood ... cells (RBCs or ... Clinical #Path #Blood ... #Smear #Microscopy
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
- Differential ... Abnormal peripheral smear ... • Extrinsic RBC ... • Intrinsic RBC ... #Differential #
Babesia spp. on Peripheral Blood Smear Microscopy
 - Multiple small parasites per RBC
 - "maltese cross"
on Peripheral Blood ... Smear Microscopy ... parasites per RBC ... Babesia #clinical #microscopy ... #smear
Elliptocyte - 
Note the shape of these appropriately named erythrocytes.
In addition to hereditary elliptocytosis, elliptocytes can
megaloblastic anemia ... myelophthisic anemia ... sideroblastic anemia ... Clinical #Path #BloodSmear ... #Blood #Smear #