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diagnosis hematology treatment syndrome leukemia nephrology anemia chronic cll lymphocytic acquired agglutinin algorithm amyloid amyloidosis aplastic apml cancer cardiology causes
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
- Differential ... Neurologic deficits (peripheral ... neutrophil count < 500 cells ... Vomiting, decreased urine ... #differential #
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
bone marrow and peripheral ... Smear: • Dysplastic ... blood count with differential ... smear • Bone marrow ... diagnosis #hematology #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Diagnosis: • Peripheral ... smear → small rnature-appearing ... lymphocytes, smudge cells ... Lymphocytic #Leukemia #oncology ... hemeonc #diagnosis #management
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Diagnosis and Management ... adsorption onto cancer cells ... disorders • Shear ... treatment #hematology #differential
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or ... develop leukostasis syndrome ... smear: Blasts ... • Tumor lysis syndrome ... Leukemia #Hematology #Oncology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis), MPA (microscopic ... : UA, Urine protein ... sparing of the lung periphery ... #differential # ... diagnosis #management
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... anemia) Labs: • Peripheral ... Aplastic #Anemia #oncology ... hematology #diagnosis #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cytometry • Peripheral ... smear: Smudge cells ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... diagnosis #workup #oncology
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
: • Nephrotic syndrome ... dissociation in urine ... Carpal tunnel syndrome ... Increased plasma cells ... polarized light microscopy
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - Differential ... Framework and Management ... Weakness - Dark urine ... kidney tubular cells ... hour with goal urine
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