14 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
lymphadenopathy • Blast cells ... Rapidly rising blast cells ... : Granulocytic cells ... Cells are in the ... #Hematology #Oncology
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
Plasmacytomas and Plasma-Cell ... A peripheral-blood ... 25% plasma cells ... stain) #Clinical #HONC ... #Smear #NEJM
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
- Summary Cancer ... cells can infiltrate ... • Peripheral smear ... : Smudge cells or ... basket cells can
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood ... anemia Sickled red cells ... : Sickle cell disease ... Bite cells: G6PD ... #hematology #microscopy
Prolymphocytes

In our case, the patient has T-prolymphocytic leukemia (T-PLL) not Acute Myeloid Leukemia (AML).  🔬Tumor
🔬Tumor cells are ... size lymphoid cells ... Prolymphocytes #Smear ... Peripheral #Pathology #Microscopy ... #Clinical #Blood
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
by blood cells ... blood cells, red ... blood cells or ... cells - red blood ... cells, white blood
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... non-specific red cell ... polychromatophilic cells ... hemolytic #anemia #Hematology ... #Microscopy
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
the total white blood ... cell count Basophils ... similarly to mast cells ... Chickenpox Other Causes ... #hematology #basophils
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
-> Endothelial cell ... Disease: (i.e. leukemia ... lymphoma, sickle cell ... retinal edema caused ... Retina • Ganglion cells
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 T cells ... Phagocytosis of blood ... cells + production ... ++: Hodgkin, T-cell ... lymphoma, B-cell