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management leukemia apml chronic classification cll differential differentiation emergencies gammopathy hemophagocytic hlh hodgkins lymphocytic lymphohistiocytosis lymphoma mds mgus monoclonal myelodysplasia
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
- Differential Diagnosis ... Framework HEMATOLOGIC ... neutrophil count < 500 cells ... #differential #diagnosis ... #cancer
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... Skin: - CLL cells ... smear: Smudge cells ... or basket cells ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
abnormal under the microscope ... abnormal under a microscope ... abnormal under the microscope ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Activation of CD8 T cells ... Phagocytosis of blood cells ... B-LNH), solid cancers ... treatment #summary #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
lymphadenopathy • Blast cells ... Rapidly rising blast cells ... : Granulocytic cells ... Cells are in the ... #Oncology #Diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
from mature B cells ... Reed-Sternberg cells ... B cells ... classification #hematology ... #oncology #management
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Summary Framework Hematologic ... cancer for which ... marrow plasma cells ... marrow plasma cells ... #diagnosis #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... Release from blast cells ... • Induce blast cell ... #management #hematology ... #oncology
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