30 results
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood ... Sickled red cells ... Bite cells: G6PD ... EricsMedicalLectures/ #Peripheral ... Analysis #hematology #microscopy
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
Plasmacytomas and Plasma-Cell ... A peripheral-blood ... revealed 25% plasma cells ... stain) #Clinical #HONC ... Leukemia #Smear #NEJM
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
Spur-Cell Anemia ... acanthocytes (or spur cells ... Spur cells acquire ... echinocytes (or burr cells ... #NEJM #clinical
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... non-specific red cell ... polychromatophilic cells ... (black arrow) Peripheral ... Pathology #Smear #Microscopy
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... Hereditary: • Peripheral ... History • Bite cells ... Deficiency • Sickle cells ... DAT (-) → Sickle Cell
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
bone marrow and peripheral ... leukopenia) Peripheral ... abnormal under the microscope ... abnormal under a microscope ... differential • Peripheral
Cells, Molecules, and Therapies. Shown is a simplified schematic depiction of major cell types within white-matter
Cells, Molecules ... depiction of major cell ... system and in the periphery ... DiseaseModifying #Targets #NEJM
Prolymphocytes

In our case, the patient has T-prolymphocytic leukemia (T-PLL) not Acute Myeloid Leukemia (AML).  🔬Tumor
🔬Tumor cells are ... size lymphoid cells ... Prolymphocytes #Smear #Peripheral ... #Pathology #Microscopy
A normal peripheral blood smear indicates the appropriate appearance of red blood cells, with a zone
A normal peripheral ... appearance of red blood cells ... Clinical #Path #Microscopy
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
Abnormalities: macrocytic anemia ... hematopoietic stem cells ... including peripheral ... blood myeloid cells ... NEJM Review: https