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management oncology differential syndrome algorithm anemia dermatology rheumatology acquired aplastic autoinflammatory cancer causes cell clinical comparison e1 elevatedmcv gangrenosum macrocytic
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
vasculitis • Hematologic ... myeloma, myelodysplastic ... conditions - multiple ... myeloma or myelodysplastic ... cells NEJM Review
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... Summary myelo ... = funny-shaped cells ... #Syndrome #MDS ... #treatment #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Syndromes (MDS) ... , or all three myeloid ... factor (GCSF) treatments ... #Syndromes #diagnosis ... #hematology #oncology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Formation • Multiple ... Myeloma Dysplastic ... • Myelodysplastic ... Algorithm #Causes #Hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Willebrand Syndrome - Diagnosis ... e.g. lymphoma, multiple ... myeloma, Waldenstrom ... #Management #treatment ... #hematology #differential
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
• Hypocellular myelodysplastic ... syndrome (MDS) ... aplastic anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
- Differential Diagnosis ... lymphocytes, plasma cells ... the mainstay of treatment ... the setting of multiple ... myeloma or AL amyloidosis
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
Myelodysplastic ... syndromes current treatment ... evolution to acute myeloid ... median age at diagnosis ... #algorithm #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
patients with EMD myeloma ... IFE, FLC assay Pathology ... Bone marrow Treatment ... • Multiple myeloma ... #Workup #Hematology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Sweet syndrome, MDS ... & Multiple myeloma ... /EGPA • RA Diagnosis ... affected tissue Treatment ... #diagnosis #management
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