7 results
hematology oncology algorithm autoinflammatory causes clinical differential e1 elevatedmcv gammopathy largegranular leukemia lymphocytic macrocytic macrocytosis management mgus monoclonal plasmacytoma radiology
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Multiple Myeloma ... osteolytic lesions and pathologic ... marrow plasma cells ... plasma clonal cell ... #Myeloma #Diagnosis
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Abnormalities: macrocytic anemia ... thrombocytopenia, multiple ... hematologic conditions - multiple ... hematopoietic stem cells ... cells NEJM Review
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Formation • Multiple ... Myeloma Dysplastic ... Macrocytosis, Target Cells ... #Differential #Diagnosis
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
required for dx - T-cells ... chronic LPD of NK cells ... clinical disease but cells ... are NK cells (sCD3 ... #pathology #diagnosis
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
No evidence of anemia ... marrow plasma cells ... insufficiency, Anemia ... marrow plasma cells ... Significance #hematology #diagnosis
Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions
myeloma. ... The diagnosis was ... clonal plasma cells ... #NEJM #clinical ... #myeloma
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
arises from plasma cells ... from the plasma cells ... monoclonal plasma cells ... clonal plasma cells ... • Multiple myeloma
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