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oncology autoinflammatory cell e1 hematology largegranular leukemia lymphocytic management plasmacytoma radiology raindrop rheumatology skull solitary somatic syndrome tceil tlgl vacuoles
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Multiple Myeloma ... Summary Clinical ... osteolytic lesions and pathologic ... marrow plasma cells ... #Myeloma #Diagnosis
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Somatic) Syndrome Clinical ... Syndrome: • Common Clinical ... Abnormalities: macrocytic anemia ... thrombocytopenia, multiple ... cells NEJM Review
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
Lymphocytic Leukemia Clinical ... Neutropenia (85%), anemia ... Same morphologic/clinical ... Lymphocytic #Leukemia #hemepath ... #pathology #diagnosis
Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions
myeloma. ... The diagnosis was ... clonal plasma cells ... #NEJM #clinical ... #myeloma
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
plasmacytoma) Clinical ... • No CRAB - no anemia ... patients with EMD myeloma ... IFE, FLC assay Pathology ... • Multiple myeloma
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