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diagnosis differential clinical hematology algorithm causes smear bloodsmear path management oncology dermatology hepatology nephrology peripheral classification infectiousdiseases interpretation laboratory rheumatology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... , Liver diseases ... Myelodysplastic syndrome ... , Liver diseases ... Hemolytic uremic syndrome
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood ... Sickled red cells ... : Sickle cell disease ... Bite cells: G6PD ... #Peripheral #Blood
Dacrocytes (tear drop cells) Other poikilocytes resemble a pear or teardrop. The narrow, tapered end may be
Dacrocytes (tear drop cells ... each of the above photos ... metaplasia, pernicious anemia ... some hemolytic anemias ... Path #BloodSmear #Blood
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
cell count (anemia ... Myeloproliferative Disease ... cells, red blood ... cells - red blood ... cells, white blood
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... Abnormalities: macrocytic anemia ... including peripheral blood ... myeloid cells ... NEJM Review: https
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
..A peripheral-blood ... Spur cells acquire ... resolve despite blood ... #NEJM #clinical ... #peripheral #blood
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... • Peripheral blood ... History • Bite cells ... Deficiency • Sickle cells ... malignancy, autoimmune disease
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Algorithm Normal Blood ... • Pancreatic Disease ... Myelodysplastic Syndromes ... Macrocytosis, Target Cells ... • Liver Disease
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
fragmented red blood ... In the right photo ... seen in hemolytic anemias ... hemolytic- uremic syndromes ... Path #BloodSmear #Blood
Sickle cells These photos show sickle cells on peripheral blood smears. In the left photo target cells
blood smears. ... to sickle cell disease ... no significant anemia ... thalassemia, and HbSC disease ... Path #BloodSmear #Blood
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