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diagnosis hematology oncology clinical smear bloodsmear path anemia antenatal aplastic asplenia autoinflammatory bands basophilia causes chronic cll derm differential e1
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
the total white blood ... similarly to mast cells ... Chronic myeloid leukemia ... Acute myeloid leukemia ... leukemia Hypersensitivity
Evaluation of Leukocytosis: The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages. Include
eosinophils, & basophils ... defined as white blood ... in peripheral blood ... the margins of blood ... NEUTROPHILS #WCC #BASOPHILS
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... - Blood and Bone ... eosinophilia, basophilia ... develop leukostasis syndrome ... • Tumor lysis syndrome
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
and Plasma-Cell Leukemia ... A peripheral-blood ... revealed 25% plasma cells ... Plasmacytomas #PlasmaCell #Leukemia ... #Smear #NEJM
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Skin: - CLL cells ... or basket cells ... Lymphocytosis: Absolute blood ... • Richter’s Syndrome ... • Sezary syndrome
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... cells, red blood ... cells - red blood ... cells, white blood
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... hematopoietic stem cells ... including peripheral blood ... myeloid cells ... NEJM Review: https
Some of the techniques used for Antenatal Diagnosis Amniocentesis - Chromosome/micro-array and DNA analysis -
— PCR Fetal blood ... serology - Fetal blood ... genetic analysis of cells ... surgery, e.g. laser photo-coagulation ... transfusion syndrome
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... virus (EBV) • Leukemia ... result from low blood
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
fragmented red blood ... cells. ... In the right photo ... hemolytic- uremic syndromes ... Path #BloodSmear #Blood
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