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diagnosis hematology oncology clinical management smear bloodsmear path signs symptoms aids anemia antenatal aplastic asplenia associated autoinflammatory causes centralretinalartery chronic
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
and Plasma-Cell Leukemia ... A peripheral-blood ... revealed 25% plasma cells ... Plasmacytomas #PlasmaCell #Leukemia ... #Smear #NEJM
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... - Blood and Bone ... - Blood & BM • ... develop leukostasis syndrome ... • Tumor lysis syndrome
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Skin: - CLL cells ... or basket cells ... Lymphocytosis: Absolute blood ... • Richter’s Syndrome ... • Sezary syndrome
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... cells, red blood ... cells - red blood ... cells, white blood
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... hematopoietic stem cells ... including peripheral blood ... myeloid cells ... NEJM Review: https
Some of the techniques used for Antenatal Diagnosis Amniocentesis - Chromosome/micro-array and DNA analysis -
— PCR Fetal blood ... serology - Fetal blood ... genetic analysis of cells ... surgery, e.g. laser photo-coagulation ... transfusion syndrome
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... virus (EBV) • Leukemia ... result from low blood
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
defects) -> Abnormal blood ... Disease: (i.e. leukemia ... ) -> Increased blood ... Retina • Ganglion cells ... Occlusion #CRAO #pathophysiology
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
fragmented red blood ... cells. ... In the right photo ... hemolytic- uremic syndromes ... Path #BloodSmear #Blood
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... ABO incompatible blood ... protein C and S Pathophysiology ... Schistocytes, helmet cells
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