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diagnosis hematology oncology autoinflammatory clinical e1 honc lymphocytic mds myelodysplasia myelodysplastic plasmacell plasmacytomas rheumatology smear somatic syndromes vacuoles vexas workup
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or ... Chronic leukemia ... (Chronic Myeloid ... develop leukostasis syndrome ... • Tumor lysis syndrome
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... cytometry • Peripheral ... Lymphocytosis: Absolute blood ... aplasia • ITP ... #CLL #Chronic
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
Plasmacytomas and Plasma-Cell ... A peripheral-blood ... revealed 25% plasma cells ... Clinical #HONC #Derm ... #Smear #NEJM
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
A (AA) → Chronic ... : • Nephrotic syndrome ... Carpal tunnel syndrome ... Increased plasma cells ... Diagnostic Testing Blood
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
three myeloid hematopoiesis ... Causes • Anemia • Aplastic ... Marrow Failure • Chronic ... Myelogenous Leukemia ... Cell Leukemia
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
(12%) • giant cell ... hematopoietic stem cells ... including peripheral ... blood myeloid cells ... NEJM Review: https
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