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diagnosis hematology oncology clinical management rheumatology smear amyloid anemia asplenia autoinflammatory bands basophils bloodsmear chronic comparison derm dermatology differential e1
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemia): • Lymphocytes ... develop leukostasis syndrome ... • Tumor lysis syndrome ... Leukemia): • Lymphocytes ... Leukemia (CLL)
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cytometry • Peripheral ... Lymphocytosis: Absolute blood ... aplasia • ITP ... • Richter’s Syndrome ... #Lymphocytic #Leukemia
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
Plasmacytomas and Plasma-Cell ... Leukemia - Physical ... A peripheral-blood ... revealed 25% plasma cells ... #Smear #NEJM
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
bone marrow and peripheral ... ) Peripheral ... Causes • Anemia • Aplastic ... Chronic Myelogenous Leukemia ... Cell Leukemia
Evaluation of Leukocytosis: The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages. Include
, monocytes, & lymphocytes ... defined as white blood ... circulate freely in peripheral ... blood; The rest ... type in the peripheral
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... virus (EBV) • Leukemia ... anemia) Labs: • Peripheral ... result from low blood
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
: • Nephrotic syndrome ... Carpal tunnel syndrome ... Lymphocyte Proliferation ... Increased plasma cells ... Diagnostic Testing Blood
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
(12%) • giant cell ... hematopoietic stem cells ... including peripheral ... blood myeloid cells ... NEJM Review: https
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... glands: • Focal lymphocytic ... neuropathy • Peripheral ... UIP, NSIP): • Lymphocytic ... PE, Pulmonary amyloidosis
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
hands and facei peripheral ... biopsy demonstrates lymphocytes ... , plasma cells, ... myeloma or AL amyloidosis ... be seen after blood
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