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smear bloodsmear diagnosis rheumatology asplenia autoinflammatory causes classification codocytes dacrocytes differential e1 elevation howell howelljolly howelljollybody jolly lactate lactic management
Dacrocytes (tear drop cells) Other poikilocytes resemble a pear or teardrop. The narrow, tapered end may be
Dacrocytes (tear drop cells ... each of the above photos ... some hemolytic anemias ... #Clinical #Path ... #BloodSmear #Blood
Codocytes (Target cells) - Two target cells are seen in the left photo and one in
seen in the left photo ... present in the left photo ... with hemolytic anemias ... #Clinical #Path ... #BloodSmear #Blood
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
fragmented red blood ... In the right photo ... hemolytic- uremic syndromes ... #Clinical #Path ... #BloodSmear #Blood
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
..A peripheral-blood ... definitively treated by liver ... candidate for liver ... #NEJM #clinical ... #peripheral #blood
Sickle cells These photos show sickle cells on peripheral blood smears. In the left photo target cells
blood smears. ... trait do very well clinically ... no significant anemia ... #Clinical #Path ... #BloodSmear #Blood
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... : • Common Clinical ... Abnormalities: macrocytic anemia ... including peripheral blood ... NEJM Review: https
Spherocytes - The arrow points to one of many spherocytes in this photo. The cells have
spherocytes in this photo ... The cells have assumed ... and hemolytic anemias ... #Clinical #Path ... #BloodSmear #Blood
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
removal from the blood ... e.g., uptake by cells ... of lactate as a clinical ... - Compartment syndrome ... 30mmHg) - Severe anemia
Howell-Jolly Body - On these Wright-stained peripheral blood smears the small dark spheres within red cells
Wright-stained peripheral blood ... poikilocyte in the left photo ... in the right photo ... #Clinical #Path ... #BloodSmear #Blood
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... ducts Clinical ... Pulmonary amyloidosis, PAH ... vasculitis: 10%-16% Liver ... renal tubular acidosis
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