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diagnosis differential hematology clinical management algorithm anemia causes nephrology smear bloodsmear classification hepatology leukemia liver path rheumatology acidosis agglutinin amyloid
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myeloproliferative Disease ... cells, red blood ... cells - red blood ... cells, white blood ... diagnosis #hematology #oncology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... hematopoietic stem cells ... including peripheral blood ... myeloid cells ... NEJM Review: https
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... anemia, Liver diseases ... Myelodysplastic syndrome ... , Liver diseases ... Hemolytic uremic syndrome
Sickle cells These photos show sickle cells on peripheral blood smears. In the left photo target cells
photos show sickle ... blood smears. ... to sickle cell disease ... thalassemia, and HbSC disease ... Path #BloodSmear #Blood
Castleman's Disease and Associated Syndromes HYALINE VASCULAR VARIANT • unicentric, HHV8-ve, children and young. • Hyalinized vessels
Castleman's Disease ... and Associated Syndromes ... • Hyalinizeä blood ... Diffuse plasma cells ... Pathogenesis "IL6 syndrome
Some of the techniques used for Antenatal Diagnosis Amniocentesis - Chromosome/micro-array and DNA analysis -
— PCR Fetal blood ... serology - Fetal blood ... genetic analysis of cells ... surgery, e.g. laser photo-coagulation ... transfusion syndrome
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... result from low blood ... Aplastic #Anemia #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... extramedullary disease ... develop leukostasis syndrome ... • Tumor lysis syndrome ... Leukemia #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
can indicate disease ... Lymphocytosis: Absolute blood ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... diagnosis #workup #oncology
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
fragmented red blood ... cells. ... In the right photo ... hemolytic- uremic syndromes ... Path #BloodSmear #Blood
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