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dermatology clinical gangrenosum rheumatology colitis derm differential e1 management oncology pg pustular sapho skin somatic sweet ulcer ulcerative vacuoles vexas
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
enzyme, X-linked, Autoinflammatory ... chondritis, skin lesions ... blood myeloid cells ... NEJM Review: https ... #E1 #Xlinked #Autoinflammatory
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
skin and mucosal lesions ... dermatoses are autoinflammatory ... DDX: - Pyoderma ... Leukemia cutis Diagnosis ... #diagnosis #dermatology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Etiology unknown: Autoinflammatory ... Pustular skin lesions ... • A clinical diagnosis ... , breast bone, pelvis ... #Rheumatology #diagnosis
Pustular Skin Lesions - Differential Diagnosis Framework What are pustules? • Pustules < 5-10 mm + pus • Material
Pustular Skin Lesions ... - Differential Diagnosis ... of inflammatory cells ... SAPHO syndrome ( ... Pyoderma gangrenosum
Pyoderma Gangrenosum in Ulcerative Colitis- ...left chest (Panel A) and leg (Panel B). The physical examination
Pyoderma Gangrenosum ... from the chest lesion ... A diagnosis of pyoderma ... #clinical #photo ... #NEJM #pyoderma
Pyoderma Gangrenosum (PG) 50 M Crohn’s dz had a small pustule on the ankle 4 mo ago
Diagnosis? ... considered an autoinflammatory ... neutrophils & T-cells ... dysregulation➡️lesions ... #PG #clinical #photo
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