12 results
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
production of inflammatory ... Recruitment of inflammatory ... cells • ANS activation ... #pathophysiology ... #immunology
Anaphylaxis: Treatments (Acute)
Additional Info:
 • IV steroids may be considered for prevention of late phase reactions.
Anaphylaxis: Treatments ... Treatment: • ... Ventolin inhaler #Anaphylaxis ... #pathophysiology ... #immunology
Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... Natural Killer Cells ... cell activity #Inflammatory ... #Inflammation #pathophysiology ... #immunology
Inflammatory mechanism of asthma. 
Airway epithelial cells exposed to activation stimuli, including allergens, viruses, and irritants,
Inflammatory mechanism ... the release of inflammatory ... #asthma #pathophysiology ... #inflammatory # ... immunology
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
release the pro-inflammatory ... secretion • Inflammatory ... conjunctivitis • Anaphylaxis ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Local and systemic anaphylaxis ... with cytotoxic T cells ... natural killer cells ... activation provides inflammatory ... Classification #Pathophysiology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... Release from blast cells ... PE, DAH, CHF, Anaphylaxis ... Renal Failure Treatment
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Activation of CD8 T cells ... production of pro-inflammatory ... Unknown cause Treatment ... diagnosis #management #treatment
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... - Microglial cells ... are the immune cells ... can become pro-inflammatory ... diagnosis column Treatment
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
Reconstitution Inflammatory ... with exaggerated inflammatory ... Virologic and immunologic ... increase in CD4+ cells ... Reconstitution #Inflammatory