11 results
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
• Or brainstem syndromes ... • Lhermitte’s sign ... symptoms) • Acute ... #diagnosis #management ... #neurology #treatment
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
Pathophysiology ... - Microglial cells ... are the immune cells ... between nerve cells ... #management
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... - ACS, AKI, acute ... WBC >100k, + lab signs ... Lysis of tumor cells ... TLS #diagnosis #management
Bell's Palsy - Diagnosis and Management Summary - GrepMed Handbook

Acute Idiopathic Unilateral Facial Nerve (CN7) Palsy
Presentation:
Bell's Palsy - Diagnosis ... GrepMed Handbook Acute ... ophthalmoplegia), systemic signs ... within 4m #Bells ... #Treatment #Neurology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Release from blast cells ... Differentiation #Syndrome ... APML #diagnosis #management
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... survival is 93-95% Pathophysiology ... tissue: Epithelioid cells ... Sarcoidosis #Diagnosis #Management ... #Signs #Symptoms
Avascular Necrosis: Pathogenesis and Clinical Findings
 • Physical Trauma (esp. to the scaphoid bone with damage
affected) - Acute ... hematopoietic marrow cells ... Findings • Sclerosis ... AvascularNecrosis #pathophysiology ... #diagnosis #signs
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... • Bilateral signs ... Pleocytosis > 100 cells ... : - Multiple sclerosis ... Myelitis #diagnosis #management
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
, particularly scleritis ... purpura: Strong sign ... Multinucleated giant cells ... (PR3-ANCA)): Microscopic ... vasculitis • Cogan syndrome
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... • Gitelman's syndrome ... apical membrane of cells ... #diagnosis #nephrology ... #management #pathophysiology