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diagnosis management differential neurology agammaglobulinemia algorithm amyotrophic classification disorders immunity lateral leukostasis lymphomas lymphoproliferative lysis myelitis nonhodgkin ophthalmology retinoblastoma sclerosis
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
Humoral Immunity ... patient (via trauma, tumor ... repeat exposure #Humoral ... #Immunity #pathophysiology ... #immunology
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings The epidemiology of this disease is 1/340,000 births and roughly double
maturation of B cells ... from precursor cells ... Absence of mature B cells ... CD19+) and plasma cells ... #immunology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... cells releasing ... diagnosis #management #hematology
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
allele of RB1 tumor ... allele of RB1 tumor ... gene mutated in all ... cells -> Mutagenic ... Retinoblastoma #pathophysiology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Reed-Sternberg (RS) Cells ... Lymphocyte - 5% RS cells ... predominant (LP) tumour ... B cells are present ... #Hematology #Diagnosis
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... - Microglial cells ... are the immune cells ... between nerve cells ... Lateral #Sclerosis #neurology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... • Bilateral signs ... Enhancement - TM and tumor ... Pleocytosis > 100 cells ... diagnosis #management #neurology
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