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diagnosis neurology hematology lysis oncology sclerosis tls treatment acromegaly amyotrophic differentiation encephalopathy endocrinology gravis immune inflammatory iris lateral leukostasis ms
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... • Pathophysiology ... cells releasing ... unless worrisome EKG ... #management #hematology
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... and AML) and solid ... with Ca only if EKG ... Walid Malki, MD, MS ... #management #UricAcid
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Release from blast cells ... initiation • Differential ... #management #hematology
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
• Or brainstem syndromes ... such as internuclear ... : • Tumor-like ... resonance imaging [MRI ... sclerosis #diagnosis #management
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... EMG: LMN Signs in ... MRI: Brain, cervical ... conditions listed in differential ... neurology #diagnosis #management
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
pancreatic islet cell tumor ... Differential Diagnosis ... Beckwith Wiedemann syndrome ... levels not useful as ... • Pituitary MRI
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
with: - Thymic tumors ... life-threatening Differential ... Generalized fatigue - ALS ... Serologic and EMG ... Gravis #diagnosis #management
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... Enhancement - TM and tumor ... Pleocytosis > 100 cells ... Myelitis #diagnosis #management ... #neurology #differential
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... survival is 93-95% Pathophysiology ... mediators such as ... of diagnosis (e.g ... anterior/posterior MSK
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Etiology: • Pathophysiology ... edema visualized as ... Vascular narrowing on MRA ... Reversible course Differential ... #diagnosis #management
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