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diagnosis management rheumatology algorithm als amyotrophic apml autoimmune bulimianervosa complications differentiation disorders eosinophil eosinophilia lateral leukostasis lysis myopathy myositis neurology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... Lysis of tumor cells ... unless worrisome EKG ... diagnosis #management #hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
workup for specific symptoms ... organ-specific signs ... or symptoms (eg ... Disorders #Algorithm #Differential ... #diagnosis #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... initiation • Differential ... diagnosis #management #hematology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... tissue: Epithelioid cells ... of diagnosis (e.g ... Diagnosis #Management #Signs ... #Symptoms
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... of UMN and LMN signs ... fasciculations Common Symptoms ... EMG: LMN Signs in ... conditions listed in differential
Palpitations - Differential Diagnosis Framework What? • It is an unpleasant awareness or sensation that the heart is
Palpitations - Differential ... exam • 12-lead ECG ... Hyperthyroidism • Anemia Psychiatric ... AVNRT Red Flag Symptoms ... #Palpitations #Cardiology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Presentation: Systemic Symptoms ... purpura: Strong sign ... Multinucleated giant cells ... • Progressive symptoms
Serotonin Syndrome: Pathogenesis and Clinical Findings Serotonin Syndrome: Variable combination of mental status changes, autonomic instability, and
Serotonin Syndrome ... drugs of abuse (e.g ... #Pathophysiology ... #Psychiatry #Diagnosis ... #Signs #Symptoms
Bulimia Nervosa: Complications GASTROINTESTINAL • Dehydration & inability to digest food -> Constipation • Recurrent vomiting exposes
• Boerhaave syndrome ... of nutrients (e.g ... Complications #pathophysiology ... #diagnosis #signs ... #symptoms #psychiatry
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... Aldolase levels • EMG ... papules and Gottron sign ... ) • Shawl sign ... #differential #
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