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diagnosis differential management causes algorithm rheumatology oncology hepatology dermatology signs symptoms systemic treatment chronic hemolytic workup classification clinical erythematosus leukemia
Hemolytic anemia in Wilson's disease #Wilsons #Disease #hemolytic #anemia #Hematology #pathophysiology
Hemolytic anemia ... in Wilson's disease ... #Wilsons #Disease ... #hemolytic #anemia ... #Hematology #pathophysiology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
, Liver diseases ... Myelodysplastic syndrome ... , Liver diseases ... Hemolytic uremic syndrome ... #differential #hematology
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Megaloblastic Anemia ... Sickled red cells ... : Sickle cell disease ... Bite cells: G6PD ... Smear #Analysis #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... vasculitis • Hematologic ... Abnormalities: macrocytic anemia ... criteria for 1) hematologic ... blood myeloid cells
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
• Pancreatic Disease ... Myelodysplastic Syndromes ... Macrocytosis, Target Cells ... • Liver Disease ... Algorithm #Causes #Hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Framework for Anemia ... chronic kidney disease ... Alcohol use, Liver disease ... Myelodysplastic syndrome ... diagnosis #causes #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... myelodysplastic syndrome ... #oncology #hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
secondary to Systemic Diseases ... Iron deficiency anemia ... • Any systemic disease ... • Nephrotic syndrome ... Systemic #Secondary #dermatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Congenital Diseases ... deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... and Autoimmune Diseases ... Differential #Diagnosis #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle cells ... Consider sickle cell disease ... ARUPLabs #Hemolytic #Anemia ... Algorithm #workup #hematology
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