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hematology management differential mds myelodysplastic workup acidosis aplastic causes cell chronic classification cll elevation foamed lactate leukemia lymphocytic myelodysplasia plasmacytoma
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... = funny-shaped cells ... cytopenias (usually anemia ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... propylthiouracil) - β-lactam ... Treatment: ... #oncology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
factor (GCSF) treatments ... marrow studies Treatment ... Immunosuppressive treatment ... #diagnosis #hematology ... #oncology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
e.g., uptake by cells ... / hypoxemia -> focus ... before beginning treatment ... - Compartment syndrome ... 30mmHg) - Severe anemia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
phenomenon CLL Diagnosis ... • Neutropenia, anemia ... microglobulin Treatment ... • Richter’s Syndrome ... #workup #oncology
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
But we also have Lactic ... for Refeeding Syndrome ... #diagnosis #differential ... #algorithm #management ... #treatment #criticalcare
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... • No CRAB - no anemia ... Bone marrow Treatment ... #Plasmacytoma #Oncology ... #Diagnosis #Workup
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