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Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoproliferative disorder ... • Symptoms of anemia ... • hemolytic anemia ... younger pts) Differential ... sensitize red blood cells
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... Pelger-Huet, Macrocytic anemia ... or λ), Smudge Cells ... Amy Chung, MD, MSc ... hematology #Markers #Differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Algorithm • Sickle cells ... Agglutination - Cold agglutinins ... Consider RBC membrane disorder
Somatoform Disorders - Differential Diagnosis Algorithm - Patient presents with complex medical problem or symptoms that
- Differential ... - Focus is the ... - Focus is appearance ... - Neurologic ... #Differential #
Causes of Secondary / Provoked Seizures - Differential Diagnosis Algorithm Febrile Infection • Sepsis • Encephalitis • Meningitis Metabolic
Provoked Seizures - Differential ... Hyponatremia • Uremia ... • Conversion Disorder ... Provoked #Seizures #Neurology ... #Differential #
Causes of Excessive Daytime Sleepiness - Differential Diagnosis Algorithm Insufficient Sleep • Poor Sleep Hygiene • Insomnia
Daytime Sleepiness - Differential ... • Neurologic ... Disorders (Eg. ... Parkinson's, MS) ... Fatigue #Sleepiness #Differential
Causes of Dizziness / Lightheadedness - Differential Diagnosis Algorithm Lightheaded, unsteady, disoriented - Non-vertigo Organic Disease • Presyncope/Vasodepressor
Lightheadedness - Differential ... Hyperventilation • Anemia ... Anxiety • Panic Disorder ... Lightheadedness #Neurology ... #Differential #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... . primary cold agglutin ... lymphoproliferative disorders ... Extravascular #Causes #differential ... diagnosis #hematology #anemia
Stroke Mimics - Differential Diagnosis - MINT Mnemonic • Metabolic: Hyper-glycemia, Hypoglycemia, Wernicke's encephalopathy, Mitochondrial Encephalopathy
Stroke Mimics - Differential ... • Infectious: Bell's ... CNS abscess • Neurologic ... Sclerosis, Conversion Disorder ... MINT #Mnemonic #neurology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Volume (MCV) - Differential ... • Small Bowel Disorder ... Macrocytosis, Target Cells ... #elevatedMCV #Differential
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