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oncology rheumatology treatment blood product reactions anemia aplastic bacterial causes chronic classification cll coagulation dermatology dic disease disseminated gangrenosum hemeonc
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 T cells ... Phagocytosis of blood cells ... accumulation of clinical ... Assessment • Clinical ... #management #treatment
Spontaneous Bacterial Peritonitis Clinical • Fever • Chills • Abdominal pain Diagnosis
Peritonitis Clinical ... Abdominal pain Diagnosis ... • PMN > 250 cells ... stain/culture Management ... #Hepatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
from mature B cells ... Reed-Sternberg cells ... Hodgkin Lymphoma - Clinical ... classification #hematology ... #oncology #management
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia Clinical ... number of CD34+ cells ... number of CD34+ cells ... Number of CD34+ cells ... #diagnosis #management
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Related Disease Clinical ... PET-CT Imaging (→ Diagnostic ... increased IgG4+ cells ... #management #phenotypes ... workup #treatment #rheumatology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
lymphocytes, smudge cells ... immunophenotype Clinical ... Leukemia #oncology #hematology ... #hemeonc #diagnosis ... #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
aggregate foci (>50 cells ... aggregate) of CD4 T cells ... , B cells, and plasma ... cells around salivary ... #Diagnosis #Management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
organ damage Clinical ... Schistocytes, helmet cells ... #Coagulation #diagnosis ... causes #treatment #management ... #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
donors (due to anti-HLA ... potassium from lysed cells ... #Transfusion #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
donors (due to anti-HLA ... potassium from lysed cells ... #Transfusions #diagnosis ... #management #hematology
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