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oncology product reactions treatment anemia aplastic causes classification coagulation dic disseminated hemophagocytic hodgkins intravascular lymphohistiocytosis lymphoma rheumatology summary transfusion transfusions
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 T cells ... Phagocytosis of blood ... cells + production ... accumulation of clinical ... #management #treatment
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
from mature B cells ... Hodgkin Lymphoma - Clinical ... Workup: • Full Blood ... classification #hematology ... #oncology #management
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia Clinical ... number of CD34+ cells ... number of CD34+ cells ... Number of CD34+ cells ... #diagnosis #management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... organ damage Clinical ... Schistocytes, helmet cells ... #Coagulation #diagnosis ... #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... donors (due to anti-HLA ... potassium from lysed cells ... #Transfusions #diagnosis ... #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... donors (due to anti-HLA ... potassium from lysed cells ... #Transfusion #diagnosis ... #management #hematology
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