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blood oncology product reactions rheumatology treatment anemia aplastic classification coagulation dermatology dic disseminated gangrenosum hemophagocytic hodgkins intravascular lymphohistiocytosis lymphoma pg
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 T cells ... Phagocytosis of blood cells ... accumulation of clinical ... Drugs, Unknown cause ... #management #treatment
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
from mature B cells ... Reed-Sternberg cells ... Hodgkin Lymphoma - Clinical ... classification #hematology ... #oncology #management
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia Clinical ... and petechiae Causes ... number of CD34+ cells ... number of CD34+ cells ... #diagnosis #management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
organ damage Clinical ... Schistocytes, helmet cells ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
aggregate foci (>50 cells ... aggregate) of CD4 T cells ... , B cells, and plasma ... cells around salivary ... #Diagnosis #Management
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... donors (due to anti-HLA ... potassium from lysed cells ... #Transfusion #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... donors (due to anti-HLA ... potassium from lysed cells ... #Transfusions #diagnosis ... #management #hematology
Pyoderma Gangrenosum (PG) 50 M Crohn’s dz had a small pustule on the ankle 4 mo ago
Diagnosis? ... wide variety of clinical ... neutrophils & T-cells ... Management of PG ... #photo #dermatology
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