14 results
Leser–Trélat Sign on Physical Exam

Acute onset of multiple seborrheic keratoses, often a paraneoplastic sign of malignancy.

#Leser
Leser–Trélat Sign ... #Leser #Trélat # ... Trelat #LeserTrelat
Back to the "10 Need to Know" series - Drug Therapeutic Target Levels. 

For lithium, target
mortality at a higher level ... Therapeutic #Ranges #Toxicology ... #Pharmacology # ... Diagnosis #Table #Monitoring
Therapeutic Drug Level Monitoring 
Carbamazepine - Sample immediately before next dose (trough) 
Clozapine - Sample immediately
Therapeutic Drug Level ... Monitoring Carbamazepine ... Sample trough level ... Therapeutic #Ranges #Toxicology ... #Pharmacology #
Heparin - Unfractionated Heparin (UFH) vs Low-Molecular-Weight Heparin (LMWH)
UFH:
 • Advantages: 
    -
- Frequent monitoring ... heparin) - Lab monitoring ... patients - If monitoring ... anti-factor Xa level ... Unfractionated #pharmacology
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... gluconeogenesis by the liver ... m2 • Severe liver ... consider routine monitoring ... #Metformin #Pharmacology
Digoxin Pharmacology and Monitoring

 • Digoxin’s half-life is 30-45 hours in healthy adults
 • When monitoring
Digoxin Pharmacology ... and Monitoring ... - Any level ... Kat_Watson #Digoxin #Pharmacology ... #Monitoring #toxicology
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... metabolized in the liver ... #Clozapine #Toxicology ... Toxicity #Diagnosis #Pharmacology
Management of Convulsive Status Epilepticus in children
Stabilization Phase (Seizure 0-5 minutes):
 • Check and maintain ABC
blood glucose level ... blood culture and toxicology ... Antiepileptic Drug (AED) level ... minutes with cardiac monitoring
Vancomycin Dosing and Trough Level Monitoring

Trough concentrations should be measured 30 minutes before the 4th dose
Dosing and Trough Level ... Monitoring Trough ... #Management #Pharmacology
Rasburicase Pharmacology Summary

Recombinant urate oxidase from saccharomyces
Immediate onset of action
Dosing:
 - Package insert: 0.2 mg/kg IV
Rasburicase Pharmacology ... depending on the level ... to allantoin Monitoring ... #Rasburicase #Pharmacology