Rasburicase Pharmacology Summary Recombinant urate oxidase from saccharomyces Immediate onset of action Dosing: - Package insert: 0.2 mg/kg IV once daily up to 5 days - Clinical practice: 1.5-6mg x 1 dose depending on the level of uric acid Contraindications: G6PD deficiency due to hydrogen peroxide produced from conversion of uric acid to allantoin Monitoring: repeat uric acid every 8 hours for 1-2 days until no longer at risk of cell lysis Ashley & Brooke Barlow PharmD @theABofPharmaC #Rasburicase #Pharmacology #Elitek
