19 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
recessive salt-losing ... prevalence of 1- ... thiazide-sensitive sodium-chloride ... H+ secretion → Hypokalemia ... Pathophysiology #nephrology
Hypernatremia Differential Diagnosis Algorithm - Diabetes Insipidus Workup

Step #1 - Consider the history
Step #2 - Assess
Differential Diagnosis Algorithm ... Diabetes Insipidus Workup ... Step #1 - Consider ... Uglucose Step #3 ... #Sodium #nephrology
Hypokalemia Differential Algorithm
Acidosis
 - RTA
 - Diarrhea
pH Normal 
 1. Decreased Mg 
 2. Intracellular Shift
Hypokalemia Differential ... Algorithm Acidosis ... discontinued) 3. ... Diagnosis #Causes #Workup ... #Nephrology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Once pseudohypokalemia is ruled out, causes of hypokalemia can be
Differential Diagnosis Algorithm ... discrete buckets: 1. ... transcellular shift) 3. ... #Causes #workup ... #nephrology
Treatment of hyperkalemia via kaliuresis 
step 1 = volume resuscitation if hypovolemic
step 2 = consider fludrocortisone
step
Treatment of hyperkalemia ... kaliuresis step 1 ... fludrocortisone step 3 ... diuretics #diuresis #nephrology ... #algorithm
Workup of Hypercalcemia - Differential Diagnosis Algorithm
High or Normal PTH:
 • Hyperparathyroidism: Parathyroid adenoma, Parathyroid hyperplasia,
Workup of Hypercalcemia ... Differential Diagnosis Algorithm ... Intoxication - High 1, ... Differential #Diagnosis #Algorithm ... #Workup #nephrology
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
Differential Diagnosis Algorithm ... water retention 1) ... Urine Osmolarity 3) ... Urine Sodium 4) ... #nephrology #sodium
Hypernatremia Diagnosis and Workup

Step 1 . Repeat the sodium concentration.
Step 2.  Check plasma osmolality.
NORMAL PLASMA
Diagnosis and Workup ... Step 1 . ... Repeat the sodium ... administration Step 3. ... #Algorithm #Nephrology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Differential Diagnosis Algorithm ... acidosis (type 1 ... Bartter's syndrome, Gitelman's ... differential #diagnosis #algorithm ... #causes #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... hypokalemic salt-losing ... thiazide-sensitive sodium ... thiazide-sensitive sodium ... Syndrome #diagnosis #nephrology