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management alkaline alp differential oncology product reactions workup algorithm coagulation dic disorders disseminated elevation hyophosphatasia intravascular leukemia low mds myelodysplasia
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... Intestine - Other causes ... • Placenta • Leukocytes ... - Drugs - Primary ... #Algorithm #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... - Differential Diagnosis ... plateletcount), peripheral blood ... PLT in selected cases ... #hematology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Most cases diagnosed ... deficiency • blood ... : • Other causes ... • Elevation of urinary ... Hyophosphatasia #hepatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... infiltrates (anemia, thrombocytopenia ... + distinctive primary ... #Leukemia #Hematology ... #Oncology #Diagnosis
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... decrease in most cases ... of Peripheral blood ... hematuria (without casts ... #Workup #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... cause • Correct ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Product Types: • Leukocyte ... proteins on plts, leukocytes ... severe thrombocytopenia ... #Transfusions #diagnosis ... #management #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age • 22 and 45 cases ... platelet count (thrombocytopenia ... IDUS) • Immune Thrombocytopenia ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
proteins on plts, leukocytes ... Causes purpura & ... severe thrombocytopenia ... #Transfusion #diagnosis ... #management #hematology
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