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diagnosis vasculitis dermatology classification ana antibodies causes cryoglobulins cutaneous dermatologic glomerulonephritis granulomatosis nonpalpable palpable patterns petechiae petechial physicalexam polyangiitis progressive
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Lupus Nephritis, Cryoglobulinemia ... (C-ANCA): GPA > ... Glomerulonephritis #Vasculitis #differential ... #diagnosis #algorithm ... #rheumatology
ANCA-Associated Vasculitis There are many definitions, but most come down to the presence of granulomas (pathologically or
inflammation: • Microscopic ... polyangiitis (GPA ... #Vasculitis #differential ... #diagnosis #algorithm ... #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Urticarial/LCV) - Cryoglobulinemic ... Vasculitis • ANCA ... Associated: - Microscopic ... Disease • Cogan syndrome ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
): • Microscopic ... +MPO) • Cryoglobulinemic ... mucositis - Rash ... microscopic polyarteritis ... #diagnosis #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... vasculitis/HSP • Cryoglobulinemia ... (MIXED) • ANCA ... #Diagnosis #hematology ... #rheumatology #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
syndrome in 80% ... DDX: • ANCA (Antineutrophil ... associated vasculitis - GPA ... , EGPA, microscopic ... classification #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
- Differential ... Diagnosis Algorithm ... , EGPA, Microscopic ... Measurement of antinuclear ... #Differential #
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
reticularis Differential ... purpura • Mixed cryoglobulinemia ... • Goodpasture syndrome ... #dermatology #rash ... #diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Using fluorescence microscopy ... SLE), Sjogren's Syndrome ... #patterns #rheumatology ... #diagnosis #differential
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, mucositis • Rash ... )): Microscopic ... MPO > PR3 60/ GPA ... + MPO) Cryoglobulinemic ... #Diagnosis #Rheumatology
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