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diagnosis dermatology classification causes cutaneous dermatologic glomerulonephritis granulomatosis nonpalpable palpable petechiae petechial physicalexam polyangiitis progressive purpura rapidly rpgn skin types
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Negative IF): • PR3-ANCA ... (C-ANCA): GPA > ... MPO-ANCA (P-ANCA ... #differential # ... #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... syndrome in 80% ... DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic ... classification #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis: + MPO-ANCA ... mucositis - Rash ... (Dx: GPA, EGPA, ... Serologies for Cryoglobulins ... #rheumatology #
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
ANCA Associated: ... - Microscopic ... - GPA Cutaneous ... Disease • Cogan syndrome ... #rheumatology #
ANCA-Associated Vasculitis There are many definitions, but most come down to the presence of granulomas (pathologically or
ANCA-Associated ... polyangiitis (GPA ... StanfordChiefs #ANCA ... #Vasculitis #differential ... #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
- Differential ... Diagnosis Algorithm ... , EGPA, Microscopic ... Measurement of antinuclear ... immunoglobulins & cryoglobulins
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
/HSP • Cryoglobulinemia ... (MIXED) • ANCA ... - GPA - EGPA ... #Diagnosis #hematology ... #rheumatology #
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
reticularis Differential ... purpura • Mixed cryoglobulinemia ... • Goodpasture syndrome ... #dermatology #rash ... #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... , mucositis • Rash ... )): Microscopic ... + MPO) Cryoglobulinemic ... Diagnosis #Rheumatology
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