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Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... Types: • Leukocyte ... Reaction (FNHTR ... - Allergic ... proteins on plts, leukocytes
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... the banked donor blood ... • Allergic reaction ... proteins on plts, leukocytes ... in transfused blood
Estimated Incidence of Transfusion Reactions
Graphical Depiction of transfusion reactions ordered from most highest to lowest incidence.
#Diagnosis
Reactions Graphical ... Depiction of transfusion ... reactions ordered ... #Diagnosis #Blood ... #Reactions #Events
Drug Treatment of Anaphylaxis and Allergic Reactions
First-Line Therapy 
 - Epinephrine 
 - Oxygen 
 -
Anaphylaxis and Allergic ... Reactions First-Line ... Anaphylaxis #Management #Pharmacology ... #Medications #Allergy
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... reaction. ... Sensitization" to Allergen ... Initial exposure to allergen ... histamine) into the blood
Cross-Reactivity of Penicillins and Cephalosporins

Cross reactivity of penicillin-allergic patients to cephalosporins has more to do with
of penicillin-allergic ... Cephalosporins #Allergy ... Management #Carbapenem #Reaction ... Incidence #PCN #Pharmacology
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
hypersensitivity reactions ... Mechanism of Action: Allergen-specific ... Examples: Acute transfusion ... recruitment of leucocytes ... #types #allergy
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
When the specific allergen ... - Red blood cell ... destruction after transfusion ... with mismatched blood ... #Diagnosis #Reactions
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
TRALI vs TACO - Transfusion ... Reactions TRALI ... plasma volume transfusion ... of high parity blood ... #Reactions #hematology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Crush injury • Blood ... transfusion • ... Jaundice/Hemolytic reactions ... reaction - Tumor ... Blood transfusion