33 results
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Product Types: • Leukocyte ... - Allergic ... proteins on plts, leukocytes ... Causes purpura & ... #diagnosis #management
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Allergic reaction ... proteins on plts, leukocytes ... Causes purpura & ... TRALI): Leading cause ... #diagnosis #management
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
lgE causes mast-cell ... Examples: Acute transfusion ... recruitment of leucocytes ... #types #allergy ... classification #comparison
Hypersensitivity: Definitions
 • Type I - Production of lgE Abs that bind to harmless allergens and
cell surfaces causes ... causes development ... An allergic reaction ... #Allergic #Reactions ... Classification #Diagnosis
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
: - Drug reaction ... infection - Allergic ... reaction - Atopic ... + T cells) - Allergic ... #Differential #Diagnosis
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
TRALI vs TACO - Transfusion ... Reactions TRALI ... without other cause ... #Reactions #hematology ... #diagnosis #comparison
Angioedema - Classification Diagnosis and Treatment
Types of Angioedema:
 • Acute allergic angioedema - Usually occurs with
Classification Diagnosis ... exposure • Non-allergic ... drug reaction - ... cell-mediated in > 90% of cases ... Classification #Types #Diagnosis
Hemolysis Classification - Intrinsic and Extrinsic Causes

Commentary: Another way to think of immune hemolysis would be
and Extrinsic Causes ... hemolysis, hemolytic transfusion ... reactions) - Dr ... #Differential #Diagnosis ... #Causes #Algorithm
When assessing a patient with acute dyspnea during or shortly following a transfusion, it is challenging
shortly following a transfusion ... #Diagnosis #Transfusion ... #Reaction #TRALI ... #TACO #Comparison
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... reaction, Paroxysmal ... reaction • Intrinsic ... Extravascular #Causes