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diagnosis lupus blood druginduced reactions summary activation classification comparison dil erythematosus hemophagocytic hlh hodgkins lymphohistiocytosis lymphoma mas oncology syndrome systemic
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... • Immunologic Workup ... life-threatening • Treatment ... of SLE • Evolution ... #Summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE ... Fibrin degradation products ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... • Immunologic Workup ... of SLE • Evolution ... comparison #table #rheumatology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
activation of macrophages ... • Clinical: fever ... Autoimmune diseases: SLE ... inhibitors under evaluation ... #rheumatology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Types: • Leukocyte ... proteins on plts, leukocytes ... cutaneous eruptions, diarrhea ... Transfusions #diagnosis #management ... #hematology #reactions
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
S/sx: Fever, flank ... proteins on plts, leukocytes ... cutaneous eruptions, diarrhea ... Transfusion #diagnosis #management ... #hematology #reactions
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... genes and gene products ... Hodgkin Lymphoma Workup ... classification #hematology ... #oncology #management
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
is rare in DIL, SCLE-DIL ... • Immunologic Workup ... DrugInduced #Lupus #DIL #rheumatology ... #diagnosis #treatment ... #management
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