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oncology chronic classification erythematosus lupus lymphocytic sle vasculitis workup agglutinin arteritis cancer cold gca giantcell hemeonc hemolytic hodgkins laboratory lymphoma
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... Lymphocytosis on CBC ... • Neutropenia, anemia ... #oncology #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... syndrome (Clinical ... disease) Differential ... #management #signs ... #symptoms #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... (75%): Anemia ( ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
immunophenotype Clinical ... of anemia or thrombocytopenia ... marrow failure with anemia ... #oncology #hematology ... #management
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... leukocytes. ... Tissue damage • Leukemia ... • Autoimmune diseases ... #WBC #CBC #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... of anemia include ... anemia • Cold ... #hemolytic #anemia ... #hematology #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
edema, active urine ... lymphopenia, low PLT • Anemia ... Induced Lupus: • Symptoms ... titers > 1:80 • CBC ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Diagnosis: Systemic ... Symptoms (Sx) in ... purpura: strong sign ... Lab Tests: • CBC ... #diagnosis #rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Giant cell arteritis ... Diagnosis = clinical ... complaints- anemia ... them, but urgent rheumatology ... #Symptoms #Diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis: • Systemic ... purpura: Strong sign ... pulses, bruits, or blood ... vasculitis • Behcet ... #Diagnosis #Rheumatology
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