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diagnosis management hematology neurology alzheimersdisease apml dementia differential differentiation encephalopathy geriatrics headache leukostasis lysis mnemonic oncology phantoms posterior pres reversible
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
Clinical Findings Risk ... mutations - Down syndrome ... dysfunction: myoclonic seizure ... AlzheimersDisease #Dementia #pathophysiology ... #geriatrics #diagnosis
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... - 80% have fever ... Treatment: - If febrile ... : • Pathophysiology ... dysrhythmias, seizures
Approach to Headaches - Differential Diagnosis Algorithm Red flags (PHANTOMS): • Pattern change, progressively worse, papilledema •
papilledema • Horner syndrome ... ) • Systemic symptoms ... and signs (e.g., fever ... , myalgia), seizures ... #neurology #PHANTOMS
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Etiology: • Pathophysiology ... Neurological symptoms ... Risk factors 3. ... elevated protein level ... persistent altered level
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Attempt if high risk ... Rare: DAH, acute febrile ... Diagnosis: >3 symptoms
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