34 results
Drugs and Classes Associated with DILI and Type of Liver Injury

#Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
and Type of Liver ... Injury #Medications ... #Differential # ... #LiverInjury #Hepatology ... #Pharmacology #Causes
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... Injury (DILI) ... or symptoms of liver ... disease 6-9 mo ... Drug #induced #Liver
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... • NAFLD • Cirrhosis ... (>1000): • DILI ... (Drug-induced liver ... injury) • Ischemic
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential ... Algorithm Vascular Causes ... hepatitis: < 1 • Cirrhosis ... #differential #
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... of underlying liver ... disease, liver ... support, or liver ... Injury (DILI)
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Injury (DILI) - ... for alternative causes ... Alcohol-related liver ... disease, Hepatic
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Acute Liver Injury ... - Drug-Induced liver ... hepatitis - Wilson disease ... #Differential # ... Hepatology #Diagnosis
The Liver Consult Primer - Guide to calling a consult
HPI:
 - Start with reason for consult
The Liver Consult ... Focus on prior Liver ... Gl History - Cirrhosis ... disease work up ... - Liver US
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Hepatocellular Level ... of cholestatic disease ... disease: > 2 ... hepatitis: < 1 • Cirrhosis ... chemistry #diagnosis #differential
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Etiologies of Cirrhosis ... Nonalcoholic fatty liver ... #Diagnosis #Differential ... #Hepatology #Cirrhosis ... #Causes