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diagnosis management dermatology differential disease hemophagocytic hlh lymphohistiocytosis product reactions stills treatment adultonset antimda5 antimda5dm aosd causes classification criteria dermatomyositis
Erythematous Rashes - THE ALGORITHMIC APPROACH Characterized by diffuse redness of the skin due to capillary congestion, erythematous
or absence of fever ... usually to TEN in adults ... If fever is present ... but without a fever ... #Febrile #Fever
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Daily high spiking fever ... - Fever spikes ... Fever of at least ... /splenomegaly, liver ... AOSD #diagnosis #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Differential Diagnosis Algorithm ... Red Flags: • Fever ... medication Febrile ... deficiency Work ... : • Complete blood
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... - Nonremitting fever ... thrombocytopenia • Liver ... Diagnosis #Management #Hematology ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
excessive macrophage activation ... also observed in adults ... following: • Fever ... lymph node, or liver ... management #treatment #hematology
Adult Onset Still's Disease - Yamaguchi Criteria Major criteria: - Fever >= 39C lasting >= 1 weeks
Adult Onset Still's ... criteria: - Fever ... with concomitant fever ... Abnormalities in liver ... #Major #Minor #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... Phagocytosis of blood ... • Clinical: fever ... diseases: SLE+++, Adult-onset ... treatment #summary #rheumatology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
Dermatomyositis • Fever ... onset [33-74%] • Blood ... disease and ILD • Liver ... Liver biopsies show ... Dermatomyositis #rheumatology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
S/sx: Fever, flank ... have drop in Hct, fever ... Sx include: fever ... eruptions, diarrhea, liver ... diagnosis #management #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... rheumatoid arthritis, adult-onset ... to: Arthritis, Fever ... Chronic B-cell activation ... Erythematosus #Diagnosis #Rheumatology
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