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diagnosis treatment rheumatology hematology neurology differential pulmonary coronavirus hemophagocytic hlh infectiousdiseases lymphohistiocytosis oncology signs causes coccidioidomycosis dermatology disease fungal infections
Multi-System Inflammatory Syndrome in Children (MIS-C) vs. Kawasaki Disease CDC Case Definition for MIS-C; • < 21
Multi-System Inflammatory ... Syndrome in Children ... years old with fever ... Comparison #diagnosis #peds ... #Syndrome #Children
Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2 infection (PIMS-TS) Clinical features all: fever > 101.3 F most: oxygen
Pediatric Inflammatory ... infection (PIMS-TS) Clinical ... features all: fever ... #covid19 #sarscov2 ... diagnosis #Signs #Symptoms
Summary of Infections in which Steroids play a role in treatment • TB meningitis • TB
Summary of Infections ... pneumonia • COVID ... reconstitution inflammatory ... Severe typhoid fever ... Indications #infections #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... syndromes Clinical ... multiorgan failure • Fever ... - Nonremitting fever ... ALT ↑ bilirubin level
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Summary Epidemiology ... renal failure Clinical ... General: fever, ... : ACUTE, fever, ... presentation with fever
UCSF COVID-19 Adult Clinical Evaluation Guide - Updated April 10 2020 Clinical Presentation • Fever: hospitalized pts but
UCSF COVID-19 Adult ... Presentation • Fever ... 30%; can be only symptom ... occur before other symptoms ... death • Higher inflammatory
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... - 80% have fever ... : • Pathophysiology ... TLS #diagnosis #management
Bullous Pemphigoid - Diagnosis and Management Summary Pathophysiology: Autoantibody-mediated damage to epithelial basement membrane -> separation of
Diagnosis and Management ... Summary Pathophysiology ... epidermis from dermis Clinical ... Signs/Symptoms/ ... Prodrome: pruritic, inflammatory
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Muscle Toxicity - Summary ... Clinical Presentation ... Guillain-Barré syndrome ... IU/I • SAMS clinical ... myopathy #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... production of pro-inflammatory ... : fever +++, hepatosplenomegaly ... , ↓ Fibrinogen level ... #treatment #summary
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