11 results
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... following: • Fever ... • Bicytopenia Treatment ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... • Clinical: fever ... , ↓ Fibrinogen level ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Visceral Leishmaniasis - Diagnosis and Management Summary
Species: Leishmania donovani, Leishmania infantum, Leishmania chagasi
Where: South Asia, East
Diagnosis and Management ... 2-6 months • Fever ... • Can cause Hemophagocytic ... Bilirubin, ↑BUN/Cr ... culture, PCR, K39) Treatment
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... common • Imaging: CXR ... APML #diagnosis #management ... #hematology #oncology
Kawasaki Disease (KD) - Diagnosis and Management Summary

Kawasaki Disease (KD) is the most common vasculitis of
Presentation: • Fever ... Diagnostic Criteria - Fever ... KD #vasculitis #rheumatology ... #pediatrics #diagnossi ... #management #treatment
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
, dyspnea, +/- CXR ... - 80% have fever ... organ damage • Treatment ... TLS #diagnosis #management ... #hematology
Septic Arthritis - Diagnosis and Management Summary
Clinical Exam: hot, swollen, pain with passive AND active ROM
Diagnosis and Management ... active ROM +/- fever ... arthritis diagnosis Treatment ... 90% sensitive in pediatrics ... cervical, anal Cxs
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Presentation: • Fever ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... Hodgkin Lymphoma Treatment ... cycles without XR ... classification #hematology ... #oncology #management