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diagnosis hematology anemia aplastic cyp3a4 doac emergencies hemeonc inducers inhibitors interactions management oncologic pglycoprotein
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... Cytotoxic drugs/Chemotherapy ... - β-lactam antibiotics ... aplastic anemia Treatment ... Aplastic #Anemia #oncology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
interactions) Cancer-treatment ... inducers #inhibitors #Chemotherapy ... #Oncology #Hematology ... #Interactions #Table ... #Pharmacology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Neutropenic fever ... : - Fever + ANC ... 500 → may stop antibiotics ... or HSCT - CRS: fever ... therapy - Symptoms: fever
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