11 results
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... : High spiking fever ... : high fever, CRP ... #rheumatology # ... diagnosis #management
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
correlates with time of fever ... Daily high spiking fever ... - Fever spikes ... Fever of at least ... #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
sJIA) • Adult-onset ... disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... erythematosus [SLE], AOSD
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Clinical triad: Fever ... Disease #diagnosis #management ... #treatment #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... , ↓ Fibrinogen level ... SLE+++, Adult-onset ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
night sweats, fever ... insufficiency • New-onset ... to 7 days after onset ... Endocarditis #diagnosis #management ... #cardiology
Acute Recurrent Pericarditis
= recurrence of Acute Pericarditis (AP) after free interval >4-6 weeks without symptoms, >1/4
RED FLAGS: Fever ... Subacute ≠ acute onset ... Pericarditis #diagnosis #management ... #treatment #rheumatology ... #cardiology
Gout - Diagnosis and Management Summary

3 Conditions for Gout to Manifest:
1. Hyperuricemia
2. Monosodium urate deposition in
Diagnosis and Management ... • Nocturnal onset ... 12-24 Hours • Fever ... Gout #diagnosis #management ... #treatment #rheumatology
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
night sweats, fever ... insufficiency • New-onset ... hematuria, + RF Treatment ... Persistent bacteremia/fevers ... to 7 days after onset
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD)

Pathophysiology:
Pyrophosphate produced by chondrocytes likely precipitates with calcium to
characterized by sudden onset ... Acute Pseudogout: Treatment ... acute neck pain, fever ... Deposition #Disease #Rheumatology ... #diagnosis #management