12 results
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Differential Diagnosis Algorithm ... • Pancreatic Disease ... Myelodysplastic Syndromes ... Disease #Macrocytic ... #Causes #Hematology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
suspicion of severe disease ... Rheumatology ... #Limping #NWB #Algorithm ... Pathway #Child #Peds ... #Pediatrics #Diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... highly inflammatory disease ... syndromes Clinical ... #Diagnosis #Management ... #Hematology #Rheumatology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Liver diseases ... Low serum IgG level ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Presentation: • Fever ... index < 2 • EPO Level ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... Sneddon-Wilkinson disease ... Thrombosis in vascular beds-renal ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Subacute-Acute: • Common: fever ... Differentiation #Syndrome ... APML #diagnosis #management ... #hematology #oncology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... age, however the disease ... following: • Fever ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Causes of Failure to Thrive - Differential Diagnosis Algorithm
Adequate Calorie Consumption
 - Increased Losses:
• Celiac Disease ... • Liver Disease ... Disorders • Syndromes ... #Causes #Peds # ... Pediatrics