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diagnosis hematology differential management aplastic chronic classification cll emergencies gap globulin hemeonc hemolytic hodgkins lymphocytic lymphoma mds myelodysplasia myelodysplastic oncologic
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... • Neutropenia, anemia ... leukemia #CLL ... #diagnosis #workup ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
of ALL is of B-cell ... Headaches, bone pain, fever ... , weight loss, abdominal ... - infiltrates (anemia ... #Hematology #Oncology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... • Sickle cells ... Consider sickle cell ... #workup #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... number of CD34+ cells ... virus (EBV) • Leukemia ... index < 2 • EPO Level ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Chronic Myelogenous Leukemia ... Leukemia • Idiopathic ... Workup: • Complete ... #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... Weight loss • Anemia ... Immune hemolytic anemia ... Hodgkin Lymphoma Workup ... #oncology #management
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
CT abdomen if abdominal ... full infectious work-up ... days → add fungal work-up ... Usually myeloid leukemias ... “big & sticky” cells
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... myeloma • Plasma cell ... leukemia • Solitary ... : Lymphoma, Leukemia ... anemia • Other
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
bone marrow at a level ... • No CRAB - no anemia ... #Plasmacytoma #Oncology ... #Diagnosis #Workup ... #Hematology
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