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diagnosis management differential alcoholic algorithm autoimmune causes chemistry cirrhosis tests transaminitis treatment workup aclf acute alkphos arthritis astalt biliary bilirubin
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... (Drug-induced liver ... Hepatopathy (shock liver ... ) • Non-hepatic ... LouLectures #Liver
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
(AH) • Onset ... ) or metabolic liver ... Possible drug-induced liver ... Presence of atypical laboratory ... #AH #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... disease, liver ... support, or liver ... Failure #Cirrhosis #Hepatology ... #gastroenterology
Alcoholic Hepatitis - Management Algorithm 1. Severity assessed not only by MDF (>32) but also by MELD
Alcoholic Hepatitis ... survival in severe AH ... can be bridge to Liver ... #Alcoholic #Hepatitis ... Algorithm #treatment #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Hepatocellular Level ... replaced by non-hepatic ... #differential #Hepatology ... transaminitis #LFTs
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Drugs • AIH ... • Alcoholic hepatitis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... disease to acute liver ... hepatocellular pattern of liver ... Necrosis) If mild laboratory ... #Management #Hepatology
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
) or metabolic liver ... Possible drug-induced liver ... Presence of atypical laboratory ... #Diagnosis #Hepatology ... #AIH
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Liver Chemistry ... ALT: • AST: liver ... In liver, 80% of ... primarily within liver ... #Pathophysiology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... cholestasis → Cirrhosis/Liver ... or higher • Liver ... Diagnosis: • Viral hepatitis ... malignancies, Hepatic
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